[HTML][HTML] The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1
FA Gala, SL Morrison - Journal of Biological Chemistry, 2002 - ASBMB
Immunoglobulins are glycoproteins, containing N-linked carbohydrates in the heavy chain
constant regions of all isotypes and O-linked carbohydrates in the hinge regions of human
IgA1 and IgD. A previous study showed that IgD synthesized in the presence of tunicamycin
and lacking the three N-linked glycans on the heavy chain was not secreted (Shin, SU, Wei,
DF, Amin, AR, Thorbecke, GJ, and Morrison, SL (1992) Hum. Antibodies 3, 65–74). The
contribution of each of the carbohydrates in the Fc of IgD to assembly and secretion was …
constant regions of all isotypes and O-linked carbohydrates in the hinge regions of human
IgA1 and IgD. A previous study showed that IgD synthesized in the presence of tunicamycin
and lacking the three N-linked glycans on the heavy chain was not secreted (Shin, SU, Wei,
DF, Amin, AR, Thorbecke, GJ, and Morrison, SL (1992) Hum. Antibodies 3, 65–74). The
contribution of each of the carbohydrates in the Fc of IgD to assembly and secretion was …