A human killer inhibitory receptor specific for HLA-A1, 2.
C Döhring, D Scheidegger, J Samaridis… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
Journal of immunology (Baltimore, Md.: 1950), 1996•journals.aai.org
Killer inhibitory receptors (KIRs) are transmembrane glycoproteins, expressed on NK cells
and a small subset of T cells, that inhibit cell-mediated cytotoxicity upon binding to
polymorphic MHC class I determinants on target cells. Although human KIRs specific for
HLA-C and HLA-B molecules have been characterized, none have been shown to interact
with HLA-A. Here we demonstrate that a member of the KIR cDNA family, designated
NKAT4, encodes a 70-kDa receptor specific for HLA-A3.
and a small subset of T cells, that inhibit cell-mediated cytotoxicity upon binding to
polymorphic MHC class I determinants on target cells. Although human KIRs specific for
HLA-C and HLA-B molecules have been characterized, none have been shown to interact
with HLA-A. Here we demonstrate that a member of the KIR cDNA family, designated
NKAT4, encodes a 70-kDa receptor specific for HLA-A3.
Abstract
Killer inhibitory receptors (KIRs) are transmembrane glycoproteins, expressed on NK cells and a small subset of T cells, that inhibit cell-mediated cytotoxicity upon binding to polymorphic MHC class I determinants on target cells. Although human KIRs specific for HLA-C and HLA-B molecules have been characterized, none have been shown to interact with HLA-A. Here we demonstrate that a member of the KIR cDNA family, designated NKAT4, encodes a 70-kDa receptor specific for HLA-A3.
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