Role of metabolism and receptor responsiveness in the attenuated responses to Angiotensin II in mice compared to rats
LA Cassis, J Huang, MC Gong, A Daugherty - Regulatory peptides, 2004 - Elsevier
Chronic infusion of Angiotensin II (AngII) to rats is a well-characterized model for
determining AngII physiology. Genetic manipulations have strengthened knowledge of
AngII; however, they do not permit an increase in AngII to be initiated at a selected age,
duration and dose. Therefore, exogenous AngII administration remains an important
technique to define its biological effect. We previously noted that infusion of AngII to mice
had minimal effects compared to the same dose given to rats. In this study, we compared the …
determining AngII physiology. Genetic manipulations have strengthened knowledge of
AngII; however, they do not permit an increase in AngII to be initiated at a selected age,
duration and dose. Therefore, exogenous AngII administration remains an important
technique to define its biological effect. We previously noted that infusion of AngII to mice
had minimal effects compared to the same dose given to rats. In this study, we compared the …
