Nox3 regulation by NOXO1, p47phox, and p67phox
G Cheng, D Ritsick, JD Lambeth - Journal of Biological Chemistry, 2004 - ASBMB
gp91 phox (Nox2), the catalytic subunit of the superoxide-generating respiratory burst
oxidase, is regulated by subunits p47 phox and p67 phox. Nox1, a homolog of gp91 phox, is
regulated by NOXO1 and NOXA1, homologs of p47 phox and p67 phox, respectively. For
both Nox1 and gp91 phox, an organizer protein (NOXO1 or p47 phox) cooperates with an
activator protein (NOXA1 or p67 phox) to regulate the catalytic subunit. Herein, we
investigate the subunit regulation of Nox3 compared with that of other Nox enzymes. Nox3 …
oxidase, is regulated by subunits p47 phox and p67 phox. Nox1, a homolog of gp91 phox, is
regulated by NOXO1 and NOXA1, homologs of p47 phox and p67 phox, respectively. For
both Nox1 and gp91 phox, an organizer protein (NOXO1 or p47 phox) cooperates with an
activator protein (NOXA1 or p67 phox) to regulate the catalytic subunit. Herein, we
investigate the subunit regulation of Nox3 compared with that of other Nox enzymes. Nox3 …
