Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis
MM Monick, K Cameron, J Staber, LS Powers… - Journal of Biological …, 2005 - ASBMB
Respiratory syncytial virus (RSV) preferentially infects lung epithelial cells. Infection by RSV
leads to an extended inflammatory response, characterized by the release of interleukin-8
(IL-8). Activation of ERK MAP kinase is required for both RSV-induced inflammation and the
extended survival of infected cells. In this study, we analyzed the role of the epidermal
growth factor receptor (EGFR) in RSV activation of ERK. We demonstrate for the first time
that RSV activates EGFR in lung epithelial cells. Activation of EGFR results in increased …
leads to an extended inflammatory response, characterized by the release of interleukin-8
(IL-8). Activation of ERK MAP kinase is required for both RSV-induced inflammation and the
extended survival of infected cells. In this study, we analyzed the role of the epidermal
growth factor receptor (EGFR) in RSV activation of ERK. We demonstrate for the first time
that RSV activates EGFR in lung epithelial cells. Activation of EGFR results in increased …
