Regression of nephropathy developed in diabetes by (Pro) renin receptor blockade
H Takahashi, A Ichihara, Y Kaneshiro… - Journal of the …, 2007 - journals.lww.com
Activation of prorenin by (pro) renin receptor stimulates the tissue renin-angiotensin system
and plays a significant role in the development of nephropathy in diabetic animals. This
study examined whether (pro) renin receptor blockade inhibits the progression of
nephropathy that has already developed in diabetic rats. Seventeen-week-old
heminephrectomized streptozotocin-induced diabetic rats with an increased urinary protein
excretion and a significant glomerulosclerosis had been treated for 12 wk with the (pro) …
and plays a significant role in the development of nephropathy in diabetic animals. This
study examined whether (pro) renin receptor blockade inhibits the progression of
nephropathy that has already developed in diabetic rats. Seventeen-week-old
heminephrectomized streptozotocin-induced diabetic rats with an increased urinary protein
excretion and a significant glomerulosclerosis had been treated for 12 wk with the (pro) …