Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C
C Feistritzer, DH Sturn, NC Kaneider, A Djanani… - Journal of allergy and …, 2003 - Elsevier
Background: Eosinophil infiltration is a characteristic feature of allergic inflammation. Allergic
responses are associated with local activation of the coagulation pathway and accumulation
of fibrin. Objective: We tested whether protein C and activated protein C (APC), which are
endogenous anti-inflammatory coagulation inhibitors, affect eosinophil function. Methods:
Eosinophils were from venous blood of healthy donors. Cell migration and apoptosis were
studied by using micropore filter assays and fluorometry, respectively. Receptor expression …
responses are associated with local activation of the coagulation pathway and accumulation
of fibrin. Objective: We tested whether protein C and activated protein C (APC), which are
endogenous anti-inflammatory coagulation inhibitors, affect eosinophil function. Methods:
Eosinophils were from venous blood of healthy donors. Cell migration and apoptosis were
studied by using micropore filter assays and fluorometry, respectively. Receptor expression …