Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis
X Shi-Wen, A Leask, D Abraham - Cytokine & growth factor reviews, 2008 - Elsevier
Connective tissue growth factor (CTGF, CCN2) is a secreted protein with major roles in
angiogenesis, chondrogenesis, osteogenesis, tissue repair, cancer and fibrosis. It is a
member of the CCN family of immediate-early gene products which are characterised by
four discrete protein modules in which reside growth factor binding domains, functional
motifs for integrin recognition, heparin and proteoglycan binding, and dimerization motifs. A
primary function of CTGF is to modulate and coordinate signaling responses involving cell …
angiogenesis, chondrogenesis, osteogenesis, tissue repair, cancer and fibrosis. It is a
member of the CCN family of immediate-early gene products which are characterised by
four discrete protein modules in which reside growth factor binding domains, functional
motifs for integrin recognition, heparin and proteoglycan binding, and dimerization motifs. A
primary function of CTGF is to modulate and coordinate signaling responses involving cell …
