Sox9 induces testis development in XX transgenic mice
VPI Vidal, MC Chaboissier, DG de Rooij, A Schedl - Nature genetics, 2001 - nature.com
VPI Vidal, MC Chaboissier, DG de Rooij, A Schedl
Nature genetics, 2001•nature.comMutations in SOX9 are associated with male-to-female sex reversal in humans 1, 2. To
analyze Sox9 function during sex determination, we ectopically expressed this gene in XX
gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating
that it can substitute for the sex-determining gene Sry.
analyze Sox9 function during sex determination, we ectopically expressed this gene in XX
gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating
that it can substitute for the sex-determining gene Sry.
Abstract
Mutations in SOX9 are associated with male-to-female sex reversal in humans 1, 2. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.
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