Chemistry-based studies on oxidative DNA damage: formation, repair, and mutagenesis
H Kasai - Free Radical Biology and Medicine, 2002 - Elsevier
H Kasai
Free Radical Biology and Medicine, 2002•ElsevierSince the discovery of 8-OH-dG formation, various aspects of oxidative DNA damage have
been studied. For example, 2-OH-dA and a glyoxal-dG adduct were discovered as new
types of oxidative DNA damage; 2-OH-dATP was found to induce mutations and to be a
good substrate of a nucleotide sanitization enzyme, the MTH1 protein; and efforts were
continued to establish standard methodologies for 8-OH-dG analyses in urine and cellular
DNA. By these studies, we found solid chemistry-based approaches were often useful to …
been studied. For example, 2-OH-dA and a glyoxal-dG adduct were discovered as new
types of oxidative DNA damage; 2-OH-dATP was found to induce mutations and to be a
good substrate of a nucleotide sanitization enzyme, the MTH1 protein; and efforts were
continued to establish standard methodologies for 8-OH-dG analyses in urine and cellular
DNA. By these studies, we found solid chemistry-based approaches were often useful to …
Since the discovery of 8-OH-dG formation, various aspects of oxidative DNA damage have been studied. For example, 2-OH-dA and a glyoxal-dG adduct were discovered as new types of oxidative DNA damage; 2-OH-dATP was found to induce mutations and to be a good substrate of a nucleotide sanitization enzyme, the MTH1 protein; and efforts were continued to establish standard methodologies for 8-OH-dG analyses in urine and cellular DNA. By these studies, we found solid chemistry-based approaches were often useful to clarify the biological phenomena.
Elsevier
