An antibody that prevents the hemagglutinin low pH fusogenic transition
C Barbey-Martin, B Gigant, T Bizebard, LJ Calder… - Virology, 2002 - Elsevier
C Barbey-Martin, B Gigant, T Bizebard, LJ Calder, SA Wharton, JJ Skehel, M Knossow
Virology, 2002•ElsevierWe have determined the structure of a complex of influenza hemagglutinin (HA) with an
antibody that binds simultaneously to the membrane-distal domains of two HA monomers,
effectively cross-linking them. The antibody prevents the low pH structural transition of HA
that is required for its membrane fusion activity, providing evidence that a rearrangement of
HA membrane-distal domains is an essential component of the transition.
antibody that binds simultaneously to the membrane-distal domains of two HA monomers,
effectively cross-linking them. The antibody prevents the low pH structural transition of HA
that is required for its membrane fusion activity, providing evidence that a rearrangement of
HA membrane-distal domains is an essential component of the transition.
We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.
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