[HTML][HTML] Endocytosis of the type III transforming growth factor-β (TGF-β) receptor through the clathrin-independent/lipid raft pathway regulates TGF-β signaling and …
Transforming growth factor-β (TGF-β) signals through three highly conserved cell surface
receptors, the type III TGF-β receptor (TβRIII), the type II TGF-β receptor (TβRII), and the type
I TGF-β receptor (TβRI) to regulate diverse cellular processes including cell proliferation,
differentiation, migration, and apoptosis. Although TβRI and TβRII undergo ligand-
independent endocytosis by both clathrin-mediated endocytosis, resulting in enhanced
signaling, and clathrin-independent endocytosis, resulting in receptor degradation, the …
receptors, the type III TGF-β receptor (TβRIII), the type II TGF-β receptor (TβRII), and the type
I TGF-β receptor (TβRI) to regulate diverse cellular processes including cell proliferation,
differentiation, migration, and apoptosis. Although TβRI and TβRII undergo ligand-
independent endocytosis by both clathrin-mediated endocytosis, resulting in enhanced
signaling, and clathrin-independent endocytosis, resulting in receptor degradation, the …
