The cell danger response (CDR) is the evolutionarily conserved metabolic response that
protects cells and hosts from harm. It is triggered by encounters with chemical, physical, or
biological threats that exceed the cellular capacity for homeostasis. The resulting metabolic
mismatch between available resources and functional capacity produces a cascade of
changes in cellular electron flow, oxygen consumption, redox, membrane fluidity, lipid
dynamics, bioenergetics, carbon and sulfur resource allocation, protein folding and …