Distinct regulation of gene expression in human endothelial cells by TGF-β and its receptors
X Wu, J Ma, JD Han, N Wang, YG Chen - Microvascular research, 2006 - Elsevier
Transforming growth factor beta (TGF-β) and its signaling mediators play essential roles in
angiogenesis—formation of new blood vessels, as evidenced by targeted gene disruption in
mice and their mutations in human vascular dysplasia. However, little is known about the
molecular basis of TGF-β function in vascular formation. To study the function of TGF-β
signaling in angiogenesis and to elucidate the signaling specificity of TGF-β receptors at the
gene transcriptional level, we analyzed the expression profile of the genes regulated by TGF …
angiogenesis—formation of new blood vessels, as evidenced by targeted gene disruption in
mice and their mutations in human vascular dysplasia. However, little is known about the
molecular basis of TGF-β function in vascular formation. To study the function of TGF-β
signaling in angiogenesis and to elucidate the signaling specificity of TGF-β receptors at the
gene transcriptional level, we analyzed the expression profile of the genes regulated by TGF …
