[HTML][HTML] Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose …
YQ Liu, JA Moibi, JL Leahy - Journal of Biological Chemistry, 2004 - ASBMB
In islet β-cells, the high expression of pyruvate carboxylase and the functional importance of
the downstream anaplerosis pathways result in a unique characteristic whereby high
glucose and fatty acids both increase production of a key fatty acid metabolite, long chain
acyl-CoA, for signaling and enzyme regulation in β-cells. We showed previously in islets that
pyruvate dehydrogenase (PDH) activity is lowered by excess fatty acids (the so-called
Randle effect). We have now investigated PDH activity and pyruvate metabolism in islets …
the downstream anaplerosis pathways result in a unique characteristic whereby high
glucose and fatty acids both increase production of a key fatty acid metabolite, long chain
acyl-CoA, for signaling and enzyme regulation in β-cells. We showed previously in islets that
pyruvate dehydrogenase (PDH) activity is lowered by excess fatty acids (the so-called
Randle effect). We have now investigated PDH activity and pyruvate metabolism in islets …
