[HTML][HTML] Impact of polymorphisms of the major histocompatibility complex class II, interleukin‐10, tumor necrosis factor‐α and cytotoxic T‐lymphocyte antigen‐4 genes …
A Pavlova, D Delev, S Lacroix‐Desmazes… - Journal of Thrombosis …, 2009 - Elsevier
Background: Approximately 25% of severe hemophilia A (HA) patients develop antibodies to
factor VIII protein. Patients: In the present case‐controlled cohort study, 260 severely
affected, mutation‐type‐matched HA patients were studied for association of human
leukocyte antigen (HLA) class II molecules and polymorphisms in the genes encoding
interleukin‐10 (IL‐10), tumor necrosis factor‐α (TNF‐α) and cytotoxic T‐lymphocyte antigen‐
4 (CTLA‐4) and development of inhibitors. Results: Our results demonstrate a higher …
factor VIII protein. Patients: In the present case‐controlled cohort study, 260 severely
affected, mutation‐type‐matched HA patients were studied for association of human
leukocyte antigen (HLA) class II molecules and polymorphisms in the genes encoding
interleukin‐10 (IL‐10), tumor necrosis factor‐α (TNF‐α) and cytotoxic T‐lymphocyte antigen‐
4 (CTLA‐4) and development of inhibitors. Results: Our results demonstrate a higher …