[HTML][HTML] Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8
I Delint-Ramirez, D Willoughby, GVR Hammond… - Journal of biological …, 2011 - ASBMB
PKA anchoring proteins (AKAPs) optimize the efficiency of cAMP signaling by clustering
interacting partners. Recently, AKAP79 has been reported to directly bind to adenylyl
cyclase type 8 (AC8) and to regulate its responsiveness to store-operated Ca 2+ entry
(SOCE). Although AKAP79 is well targeted to the plasma membrane via phospholipid
associations with three N-terminal polybasic regions, recent studies suggest that AKAP79
also has the potential to be palmitoylated, which may specifically allow it to target the lipid …
interacting partners. Recently, AKAP79 has been reported to directly bind to adenylyl
cyclase type 8 (AC8) and to regulate its responsiveness to store-operated Ca 2+ entry
(SOCE). Although AKAP79 is well targeted to the plasma membrane via phospholipid
associations with three N-terminal polybasic regions, recent studies suggest that AKAP79
also has the potential to be palmitoylated, which may specifically allow it to target the lipid …
