Synthesis and preliminary evaluation of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl) guanine ([18F] FHBG): a new potential imaging agent for viral infection and gene …
MM Alauddin, PS Conti - Nuclear medicine and biology, 1998 - Elsevier
Synthesis and preliminary biological evaluation of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl)
guanine ([18F] FHBG) is reported. 9-(4-Hydroxy-3-hydroxymethylbutyl)-guanine (penciclovir)
4 was converted to 9-[N2, O-bis-(methoxytrityl)-3-(tosylmethybutyl)] guanine 7 by treatment
with methoxytrityl chloride followed by tosylation. The tosylate 7 was reacted with either
tetrabutylammonium fluoride or KF in the presence of kryptofix 2.2. 2. to produce the 4-fluoro-
N2-O-bis-(methoxytrityl) derivative 8. Removal of the methoxytrityl groups by acidic …
guanine ([18F] FHBG) is reported. 9-(4-Hydroxy-3-hydroxymethylbutyl)-guanine (penciclovir)
4 was converted to 9-[N2, O-bis-(methoxytrityl)-3-(tosylmethybutyl)] guanine 7 by treatment
with methoxytrityl chloride followed by tosylation. The tosylate 7 was reacted with either
tetrabutylammonium fluoride or KF in the presence of kryptofix 2.2. 2. to produce the 4-fluoro-
N2-O-bis-(methoxytrityl) derivative 8. Removal of the methoxytrityl groups by acidic …