Targeting hyaluronic acid production for the treatment of leukemia: treatment with 4-methylumbelliferone leads to induction of MAPK-mediated apoptosis in K562 …
ON Uchakina, H Ban, RJ McKallip - Leukemia research, 2013 - Elsevier
The current study examined the effect of modulation of hyaluronic acid (HA) synthesis on
leukemia cell survival using the hyaluronic acid synthesis inhibitor 4-methylumbelliferone (4-
MU). Treatment of CML cells with 4-MU led to caspase-dependent apoptosis characterized
by decreased HA production, PARP cleavage, and increased phosphorylation of p38.
Addition of exogenous HA, the pan caspase inhibitor Z-VAD-FMK or the p38 inhibitor
SB203580 to 4-MU treated cells was able to protect cells from apoptosis. Treatment of tumor …
leukemia cell survival using the hyaluronic acid synthesis inhibitor 4-methylumbelliferone (4-
MU). Treatment of CML cells with 4-MU led to caspase-dependent apoptosis characterized
by decreased HA production, PARP cleavage, and increased phosphorylation of p38.
Addition of exogenous HA, the pan caspase inhibitor Z-VAD-FMK or the p38 inhibitor
SB203580 to 4-MU treated cells was able to protect cells from apoptosis. Treatment of tumor …
