Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic …
H Sic, H Kraus, J Madl, KA Flittner… - Journal of Allergy and …, 2014 - Elsevier
Background Five different G protein–coupled sphingosine-1-phosphate (S1P) receptors
(S1P1-S1P5) regulate a variety of physiologic and pathophysiologic processes, including
lymphocyte circulation, multiple sclerosis (MS), and cancer. Although B-lymphocyte
circulation plays an important role in these processes and is essential for normal immune
responses, little is known about S1P receptors in human B cells. Objective To explore their
function and signaling, we studied B-cell lines and primary B cells from control subjects …
(S1P1-S1P5) regulate a variety of physiologic and pathophysiologic processes, including
lymphocyte circulation, multiple sclerosis (MS), and cancer. Although B-lymphocyte
circulation plays an important role in these processes and is essential for normal immune
responses, little is known about S1P receptors in human B cells. Objective To explore their
function and signaling, we studied B-cell lines and primary B cells from control subjects …
