Exosomes are part of the family of “bioactive vesicles” and appear to be involved in distal
communications between cells. They vehiculate bioactive lipids and lipolytic enzymes and
their biogenesis require specific lipids and a membrane reorganisation. Their biogenesis
pathway could be a way to secrete enzymes involved in lipid signalling and to generate
“particulate agonists”. However, this pathway seems also to be used by pathogens such as
HIV. This review will consider several aspects of lipidomics studies which might help to …