Effect of castration and sex hormones on experimental autoimmune thyroiditis
I Okayasu, MK Yi-chi, NR Rose - Clinical immunology and …, 1981 - Elsevier
To determine the effect of sex hormones on experimental autoimmune thyroiditis, male and
female good responder and poor responder mice were castrated at 2 or 4 weeks of age.
Following castration some groups of good responder mice were further treated with β-
estradiol or 5-α-dihydrotestosterone implants. At 9 to 11 weeks of age, autoimmune
thyroiditis was induced by injection of mouse thyroglobulin plus adjuvant. Castration
significantly increased antibody levels only in good responder male mice, an effect that was …
female good responder and poor responder mice were castrated at 2 or 4 weeks of age.
Following castration some groups of good responder mice were further treated with β-
estradiol or 5-α-dihydrotestosterone implants. At 9 to 11 weeks of age, autoimmune
thyroiditis was induced by injection of mouse thyroglobulin plus adjuvant. Castration
significantly increased antibody levels only in good responder male mice, an effect that was …