Kinetics of mononuclear cell infiltration and cytokine expression in iodine-induced thyroiditis in the NOD-H2h4 mouse
RE Bonita, NR Rose, L Rasooly, P Caturegli… - … and molecular pathology, 2003 - Elsevier
Mononuclear cell infiltration of the thyroid gland is a common histologic feature of chronic
lymphocytic thyroiditis. Although the infiltrating mononuclear cells have been implicated in
the destruction of the thyroid, information concerning the progression of infiltration into the
thyroid is limited. In this report, we examine the composition and kinetics of mononuclear cell
infiltration in the thyroid and the expression of major histocompatibility complex class II (I-
Ak), IL-12, and IFN-γ in the thyroid of the NOD-H2h4 mouse, a model of spontaneous …
lymphocytic thyroiditis. Although the infiltrating mononuclear cells have been implicated in
the destruction of the thyroid, information concerning the progression of infiltration into the
thyroid is limited. In this report, we examine the composition and kinetics of mononuclear cell
infiltration in the thyroid and the expression of major histocompatibility complex class II (I-
Ak), IL-12, and IFN-γ in the thyroid of the NOD-H2h4 mouse, a model of spontaneous …