Autoimmune regulator expression in thymomas with or without autoimmune disease
Y Liu, H Zhang, P Zhang, F Meng, Y Chen, Y Wang… - Immunology letters, 2014 - Elsevier
Background The autoimmune regulator (AIRE) regulates autoimmunity and self-antigen
expression, such as acetylcholine receptor (AchR), in the thymus. Regulatory T cells (Tregs)
can down-regulate autoimmunity, but also promote tumor growth. The objective of this study
was to examine the levels of AIRE, AchR, and Foxp3 expression in thymomas. Methods The
relative levels of AIRE, AchR, and Foxp3 mRNA transcripts and the frequency of AIRE+,
AchR+, and Foxp3+ cells were determined by quantitative RT-PCR and …
expression, such as acetylcholine receptor (AchR), in the thymus. Regulatory T cells (Tregs)
can down-regulate autoimmunity, but also promote tumor growth. The objective of this study
was to examine the levels of AIRE, AchR, and Foxp3 expression in thymomas. Methods The
relative levels of AIRE, AchR, and Foxp3 mRNA transcripts and the frequency of AIRE+,
AchR+, and Foxp3+ cells were determined by quantitative RT-PCR and …