The influence of bone marrow depletion on intestinal radiation damage
NHA Terry, EL Travis - International Journal of Radiation Oncology* Biology …, 1989 - Elsevier
These experiments were designed to test the hypothesis that bone marrow damage
contributes to lethality when the endpoint used is LD50 for gastrointestinal damage. Specific
pathogen-free mice were irradiated to the total body, total abdomen, or to the total body
followed by rescue with syngeneic bone marrow cells. The relationship between animal
survival and jejunal crypt survival was also examined under these three experimental
conditions. The LD50/10 after total abdominal irradiation (15.6 Gy) was higher than that for …
contributes to lethality when the endpoint used is LD50 for gastrointestinal damage. Specific
pathogen-free mice were irradiated to the total body, total abdomen, or to the total body
followed by rescue with syngeneic bone marrow cells. The relationship between animal
survival and jejunal crypt survival was also examined under these three experimental
conditions. The LD50/10 after total abdominal irradiation (15.6 Gy) was higher than that for …