Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients
Z Yang, A Matsumoto, K Nakayama, EF Jimbo… - Brain and …, 2016 - Elsevier
Background The genetic background of autism spectrum disorder (ASD) is considered a
multi-genetic disorder with high heritability. Autistic children present with a higher
prevalence of sleep disorders than has been observed in children with normal development.
Some circadian-relevant genes have been associated with ASD (eg, PER1, PER2, NPAS2,
MTNR1A, and MTNR1B). Methods We analyzed 28 ASD patients (14 with sleep disorders
and 14 without) and 23 control subjects of Japanese descent. The coding regions of 18 …
multi-genetic disorder with high heritability. Autistic children present with a higher
prevalence of sleep disorders than has been observed in children with normal development.
Some circadian-relevant genes have been associated with ASD (eg, PER1, PER2, NPAS2,
MTNR1A, and MTNR1B). Methods We analyzed 28 ASD patients (14 with sleep disorders
and 14 without) and 23 control subjects of Japanese descent. The coding regions of 18 …
