Dysfunctional ErbB2, an EGF receptor family member, hinders repair of airway epithelial cells from asthmatic patients
H Inoue, T Hattori, X Zhou, EB Etling… - Journal of Allergy and …, 2019 - Elsevier
Background Genetic and genomic data increasingly point to the airway epithelium as critical
to asthma pathogenesis. Epithelial growth factor (EGF) family members play a fundamental
role in epithelial differentiation, proliferation, and repair. Although expression of
erythroblastosis oncogene B2 (ErbB2) mRNA, an EGF family receptor, was reported to be
lower in asthmatic patients, little is understood about its functional role. Objective We sought
to determine whether decreased ErbB2 activation in freshly isolated human airway epithelial …
to asthma pathogenesis. Epithelial growth factor (EGF) family members play a fundamental
role in epithelial differentiation, proliferation, and repair. Although expression of
erythroblastosis oncogene B2 (ErbB2) mRNA, an EGF family receptor, was reported to be
lower in asthmatic patients, little is understood about its functional role. Objective We sought
to determine whether decreased ErbB2 activation in freshly isolated human airway epithelial …
