MiR-204 regulates type 1 IP3R to control vascular smooth muscle cell contractility and blood pressure
M Gabani, J Liu, K Ait-Aissa, O Koval, YR Kim… - Cell Calcium, 2019 - Elsevier
MiR-204 is expressed in vascular smooth muscle cells (VSMC). However, its role in VSMC
contraction is not known. We determined if miR-204 controls VSMC contractility and blood
pressure through regulation of sarcoplasmic reticulum (SR) calcium (Ca 2+) release.
Systolic blood pressure (SBP) and vasoreactivity to VSMC contractile agonists
(phenylephrine (PE), thromboxane analogue (U46619), endothelin-1 (ET-1), angiotensin-II
(Ang II) and norepinephrine (NE) were compared in aortas and mesenteric resistance …
contraction is not known. We determined if miR-204 controls VSMC contractility and blood
pressure through regulation of sarcoplasmic reticulum (SR) calcium (Ca 2+) release.
Systolic blood pressure (SBP) and vasoreactivity to VSMC contractile agonists
(phenylephrine (PE), thromboxane analogue (U46619), endothelin-1 (ET-1), angiotensin-II
(Ang II) and norepinephrine (NE) were compared in aortas and mesenteric resistance …