Effect of spironolactone on myocardial fibrosis and other clinical variables in patients with hypertrophic cardiomyopathy
MS Maron, RH Chan, NK Kapur, IZ Jaffe… - The American Journal of …, 2018 - Elsevier
Background Myocardial fibrosis has proved to be an important marker and determinant in
the pathogenesis of hypertrophic cardiomyopathy. In particular, scar formation, if substantial,
can promote ventricular tachyarrhythmias or progressive heart failure in the absence of left
ventricular outflow obstruction. Therefore, an intervention to mitigate myocardial fibrosis
would be potentially advantageous to hypertrophic cardiomyopathy patients. Methods
Eligible hypertrophic cardiomyopathy patients were randomized 1: 1 in a prospective double …
the pathogenesis of hypertrophic cardiomyopathy. In particular, scar formation, if substantial,
can promote ventricular tachyarrhythmias or progressive heart failure in the absence of left
ventricular outflow obstruction. Therefore, an intervention to mitigate myocardial fibrosis
would be potentially advantageous to hypertrophic cardiomyopathy patients. Methods
Eligible hypertrophic cardiomyopathy patients were randomized 1: 1 in a prospective double …
