Cationic antimicrobial peptides serve as the first chemical barrier between all organisms and
microbes. One of their main targets is the cytoplasmic membrane of the microorganisms.
However, it is not yet clear why some peptides are active against one particular bacterial
strain but not against others. Recent studies have suggested that the lipopolysaccharide
(LPS) outer membrane is the first protective layer that actually controls peptide binding and
insertion into Gram-negative bacteria. In order to shed light on these interactions, we …