Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2−/− mice
Abstract Background and Aims: Secretin (SCT) and secretin receptor (SR, only expressed
on cholangiocytes within the liver) play key roles in modulating liver phenotypes. Forkhead
box A2 (FoxA2) is required for normal bile duct homeostasis by preventing the excess of
cholangiocyte proliferation. Shortterm administration of the SR antagonist (SCT 5–27)
decreased ductular reaction and liver fibrosis in bile duct ligated and Mdr2−/−[primary
sclerosing cholangitis (PSC), model] mice. We aimed to evaluate the effectiveness and risks …
on cholangiocytes within the liver) play key roles in modulating liver phenotypes. Forkhead
box A2 (FoxA2) is required for normal bile duct homeostasis by preventing the excess of
cholangiocyte proliferation. Shortterm administration of the SR antagonist (SCT 5–27)
decreased ductular reaction and liver fibrosis in bile duct ligated and Mdr2−/−[primary
sclerosing cholangitis (PSC), model] mice. We aimed to evaluate the effectiveness and risks …