A critical appraisal of brown adipose tissue metabolism in humans
DP Blondin, SM Labbé, EE Turcotte, F Haman… - Clinical …, 2015 - Taylor & Francis
Clinical Lipidology, 2015•Taylor & Francis
The presence of brown adipose tissue (BAT) in adult humans has been rediscovered
through the clinical use of the radioactive glucose analog 18F-fluorodeoxyglucose with PET.
This has led to numerous studies demonstrating cold exposure as the major physiological
modulator of BAT activity. These reports also suggested that age, gender, BMI and the
presence of diabetes are also important modulators of BAT volume and metabolic activity.
Although 18F-fluorodeoxyglucose PET has provided important information on BAT glucose …
through the clinical use of the radioactive glucose analog 18F-fluorodeoxyglucose with PET.
This has led to numerous studies demonstrating cold exposure as the major physiological
modulator of BAT activity. These reports also suggested that age, gender, BMI and the
presence of diabetes are also important modulators of BAT volume and metabolic activity.
Although 18F-fluorodeoxyglucose PET has provided important information on BAT glucose …
Abstract
The presence of brown adipose tissue (BAT) in adult humans has been rediscovered through the clinical use of the radioactive glucose analog 18F-fluorodeoxyglucose with PET. This has led to numerous studies demonstrating cold exposure as the major physiological modulator of BAT activity. These reports also suggested that age, gender, BMI and the presence of diabetes are also important modulators of BAT volume and metabolic activity. Although 18F-fluorodeoxyglucose PET has provided important information on BAT glucose metabolism, other techniques are being developed and applied to assess other aspects of BAT metabolism. Here, we summarize the current understanding of the pathophysiological functions of BAT in humans and discuss some of the strengths and limitations of the current investigational techniques.
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