Cardiovascular disease risk assessment using traditional risk factors and polygenic risk scores in the million veteran program
Importance Primary prevention of atherosclerotic cardiovascular disease (ASCVD) relies on
risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve
ASCVD risk estimation. Objective To determine whether genome-wide PRSs for coronary
artery disease (CAD) and acute ischemic stroke improve ASCVD risk estimation with
traditional clinical risk factors in an ancestrally diverse midlife population. Design, Setting,
and Participants This was a prognostic analysis of incident events in a retrospectively …
risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve
ASCVD risk estimation. Objective To determine whether genome-wide PRSs for coronary
artery disease (CAD) and acute ischemic stroke improve ASCVD risk estimation with
traditional clinical risk factors in an ancestrally diverse midlife population. Design, Setting,
and Participants This was a prognostic analysis of incident events in a retrospectively …
