Evaluation of large-scale proteomics for prediction of cardiovascular events
H Helgason, T Eiriksdottir, MO Ulfarsson, A Choudhary… - JAMA, 2023 - jamanetwork.com
Importance Whether protein risk scores derived from a single plasma sample could be
useful for risk assessment for atherosclerotic cardiovascular disease (ASCVD), in
conjunction with clinical risk factors and polygenic risk scores, is uncertain. Objective To
develop protein risk scores for ASCVD risk prediction and compare them to clinical risk
factors and polygenic risk scores in primary and secondary event populations. Design,
Setting, and Participants The primary analysis was a retrospective study of primary events …
useful for risk assessment for atherosclerotic cardiovascular disease (ASCVD), in
conjunction with clinical risk factors and polygenic risk scores, is uncertain. Objective To
develop protein risk scores for ASCVD risk prediction and compare them to clinical risk
factors and polygenic risk scores in primary and secondary event populations. Design,
Setting, and Participants The primary analysis was a retrospective study of primary events …