First published April 1, 2004 - More info
Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.
David A. Hafler
Original citation: J. Clin. Invest.113:788–794 (2003). doi:10.1172/JCI21357.
Citation for this corrigendum: J. Clin. Invest.113:1070 (2004). doi:10.1172/JCI21357E1.
We failed to mention the generous grant support of the Science in Medicine series provided by the Doris Duke Charitable Foundation. We regret the omission.