Fructose metabolism and metabolic disease
Sarah A. Hannou,1 Danielle E. Haslam,2 Nicola M. McKeown,2 and Mark A. Herman1
1Division of Endocrinology and Metabolism and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.
2Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Address correspondence to: Mark A. Herman, 300 N. Duke Street, Carmichael Building, Duke University, Durham, North Carolina 27705, USA. Phone: 919.479.2378; Email: mark.herman@duke.edu.
Find articles by Hannou, S. in: JCI | PubMed | Google Scholar
1Division of Endocrinology and Metabolism and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.
2Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Address correspondence to: Mark A. Herman, 300 N. Duke Street, Carmichael Building, Duke University, Durham, North Carolina 27705, USA. Phone: 919.479.2378; Email: mark.herman@duke.edu.
Find articles by Haslam, D. in: JCI | PubMed | Google Scholar
1Division of Endocrinology and Metabolism and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.
2Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Address correspondence to: Mark A. Herman, 300 N. Duke Street, Carmichael Building, Duke University, Durham, North Carolina 27705, USA. Phone: 919.479.2378; Email: mark.herman@duke.edu.
Find articles by McKeown, N. in: JCI | PubMed | Google Scholar
1Division of Endocrinology and Metabolism and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.
2Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Address correspondence to: Mark A. Herman, 300 N. Duke Street, Carmichael Building, Duke University, Durham, North Carolina 27705, USA. Phone: 919.479.2378; Email: mark.herman@duke.edu.
Find articles by Herman, M. in: JCI | PubMed | Google Scholar
First published February 1, 2018 - More info
J Clin Invest. 2018;128(2):545–555. https://doi.org/10.1172/JCI96702.
Copyright © 2018, American Society for Clinical Investigation
Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease.
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